Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 37, Issue 1, Pages 62-72Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2015.09.001
Keywords
-
Categories
Funding
- ALSAC of St Jude Children's Research Hospital
- [5R01GM101087]
Ask authors/readers for more resources
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the signal transducer of the developmentally and therapeutically relevant Hedgehog (Hh) pathway. Although recent structural analyses have advanced our understanding of Smo biology, several questions remain. Chief among them are the identity of its natural ligand, the regulatory processes controlling its activation, and the mechanisms by which it signals to downstream effectors. In this review, we discuss recent discoveries from multiple model systems that have set the stage for solving these mysteries. We focus on the roles of distinct Smo functional domains, post-translational modifications, and trafficking, and conclude by discussing their contributions to signal output.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available