Journal
TRENDS IN PARASITOLOGY
Volume 32, Issue 1, Pages 30-42Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2015.09.008
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Funding
- Gordon and Llura Gund Foundation
- National Institutes of Health [R01 GM105246, R44HL127698]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R44HL127698] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM105246] Funding Source: NIH RePORTER
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lxodes ticks maintain a large and diverse array of human pathogens in the enzootic cycle, including Borrelia burgdorferi and Babesia microti. Despite the poor ecological fitness of B. microti, babesiosis has recently emerged in areas endemic for Lyme disease. Studies in ticks, reservoir hosts, and humans indicate that coinfection with B. burgdorferi and B. microti is common, promotes transmission and emergence of B. microti in the enzootic cycle, and causes greater disease severity and duration in humans. These interdisciplinary studies may serve as a paradigm for the study of other vector-borne coinfections. Identifying ecological drivers of pathogen emergence and host factors that fuel disease severity in coinfected individuals will help guide the design of effective preventative and therapeutic strategies.
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