Journal
TRENDS IN PARASITOLOGY
Volume 32, Issue 6, Pages 470-480Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2016.03.007
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Genetic markers for sheep resistance to gastrointestinal parasites have long been sought by the livestock industry as a way to select more resistant individuals and to help farmers reduce parasite transmission by identifying and removing high egg shedders from the flock. Polymorphisms related to the major histocompatibility complex and interferon (IFN)-gamma genes have been the most frequently reported markers associated with infection. Recently, a new picture is emerging from genome-wide studies, showing that not only immune mechanisms are important determinants of host resistance but that gastrointestinal mucus production and hemostasis pathways may also play a role.
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