Journal
TRENDS IN NEUROSCIENCES
Volume 39, Issue 4, Pages 212-220Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2016.01.004
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Funding
- National Natural Science Foundation of China [31471082]
- Royal Society
- European Research Council (ERC)
- Wellcome Trust
- BBSRC [BB/G01177X/2] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G01177X/2] Funding Source: researchfish
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How perception of pain emerges from neural activity is largely unknown. Identifying a neural 'pain signature' and deriving a way to predict perceived pain from brain activity would have enormous basic and clinical implications. Researchers are increasingly turning to functional brain imaging, often applying machine-learning algorithms to infer that pain perception occurred. Yet, such sophisticated analyses are fraught with interpretive difficulties. Here, we highlight some common and troublesome problems in the literature, and suggest methods to ensure researchers draw accurate conclusions from their results. Since functional brain imaging is increasingly finding practical applications with real-world consequences, it is critical to interpret brain scans accurately, because decisions based on neural data will only be as good as the science behind them.
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