4.6 Review

Human TBK1: A Gatekeeper of Neuroinflammation

Journal

TRENDS IN MOLECULAR MEDICINE
Volume 22, Issue 6, Pages 511-527

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2016.04.006

Keywords

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Funding

  1. Universiti Brunei Darussalam
  2. Medical Research Foundation
  3. NIH [2R01NS072381-05]
  4. ANR award IEIHSEEI
  5. Medical Research Foundation [C0483] Funding Source: researchfish

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The importance of TANK binding kinase-1 (TBK1), a multimeric kinase that modulates inflammation and autophagy, in human health has been highlighted for the first time by the recent discoveries of mutations in TBK1 that underlie amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), normal tension glaucoma (NTG) or childhood herpes simplex encephalitis (HSE). Gain-of-function of TBK1 are associated with NTG, whereas loss-of-function mutations result in ALS/FTD or in HSE. In light of these new findings, we review the role of TBK1 in these seemingly unrelated, yet allelic diseases, and discuss the role of TBK1 in neuroinflammatory diseases. This discovery has the potential to significantly increase our understanding of the molecular basis of these poorly understood diseases.

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