Journal
TRENDS IN IMMUNOLOGY
Volume 37, Issue 5, Pages 321-333Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.03.007
Keywords
-
Categories
Funding
- German Research Foundation [SFB650, TP28, LO1542/3-1]
- German Federal Ministry of Education and Research [0316164G]
- Swiss National Science Foundation [CRSII3_160772/1]
- Volkswagen Foundation
- Willy Robert Pitzer Foundation
- Swiss National Science Foundation (SNF) [CRSII3_160772] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4(+) and CD8(+) T cell activation and function, and have also revealed important distinctions. The IL-33 receptor ST2 is constitutively and abundantly expressed on T-helper-2 (Th2) and GATA-3(+) regulatory T cells in a GATA-3- and STAT5-dependent manner. Upon activation, Th1 and cytotoxic T cells express ST2 transiently, driven by T-bet and/or STAT4. We review these findings here, and critically examine evidence indicating that IL-33 enhances the differentiation and functionality of various T cell subsets through positive feedback loops involving lineage-specifying transcription factors. In this context, we discuss how quantitative and qualitative differences in ST2 expression between effector and GATA-3(+) regulatory T cells may contribute to immune homeostasis, and outline important areas of future inquiry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available