Journal
TRENDS IN IMMUNOLOGY
Volume 37, Issue 5, Pages 273-286Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.03.006
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Funding
- Wellcome Trust [098291/Z/12/Z]
- Medical Research Council [MR/M004864/1]
- Swiss National Science Foundation [SNF 310030_153456]
- Swiss Cancer Research [KFS-2914-02-2012]
- MRC [MR/K006312/1, MR/M004864/1] Funding Source: UKRI
- Medical Research Council [MR/M004864/1, MR/K006312/1] Funding Source: researchfish
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Neutrophil migration to injured and pathogen-infected tissues is a fundamental component of innate immunity. An array of cellular and molecular events mediate this response to collectively guide neutrophils out of the vasculature and towards the core of the ensuing inflammatory reaction where they exert effector functions. Advances in imaging modalities have revealed that neutrophils can also exhibit motility away from sites of inflammation and injury, although it is unclear under what circumstances this reverse migration is a physiological protective response, and when it has pathophysiological relevance. Here we review different types of neutrophil reverse migration and discuss the current understanding of the associated mechanisms. In this context we propose clarifications to the existing terminology used to describe the many facets of neutrophil reverse migration.
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