Journal
TRENDS IN IMMUNOLOGY
Volume 37, Issue 1, Pages 68-79Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2015.11.003
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Funding
- National Institutes of Health [R01AI0 74745, R01DK0 76616, 1S10RR 02829, R01AI0 80769]
- National Multiple Sclerosis Society
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR002829] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI080769, R01AI074745] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK076616] Funding Source: NIH RePORTER
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Innate lymphoid cell (ILCs) subsets differentially populate various barrier and non-barrier tissues, where they play important roles in tissue homeostasis and tissue-specific responses to pathogen attack. Recent findings have provided insight into the molecular mechanisms that guide ILC migration into peripheral tissues, revealing common features among different ILC subsets as well as important distinctions. Recent studies have also highlighted the impact of tissue-specific cues on ILC migration, and the importance of the local immunological milieu. We review these findings here and discuss how the migratory patterns and tissue tropism of different ILC subsets relate to the development and differentiation of these cells, and to ILC-mediated tissue-specific regulation of innate and adaptive immune responses. In this context we outline open questions and important areas of future research.
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