Journal
TRENDS IN IMMUNOLOGY
Volume 37, Issue 1, Pages 17-31Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2015.11.007
Keywords
-
Categories
Funding
- National Institutes of Heath [AI089954, DK105562]
- Cancer Research Institute Investigator Award
- Pew Charitable Trusts
- Burroughs Wellcome Fund
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI089954, R21AI091962] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK105562] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The aryl hydrocarbon receptor (AHR) is an important regulator of the development and function of both innate and adaptive immune cells through roles associated with AHR's ability to respond to cellular and dietary ligands. Recent findings have revealed tissue and context-specific functions for AHR in both homeostasis and in during an immune response. I review these findings here, and integrate them into the current understanding of the mechanisms that regulate AHR transcription and function. I propose a conceptual framework in which AHR function is determined by three factors: the amount of AHR in any given cell, the abundance and potency of AHR ligands within certain tissues, and the tissue microenvironment wherein AHR(+) cells reside. This complexity emphasizes the necessity cell-type specific genetic approaches towards the study of AHR function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available