Journal
TRENDS IN IMMUNOLOGY
Volume 37, Issue 9, Pages 569-570Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.07.004
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Funding
- Biotechnology and Biological Sciences Research Council [1360485] Funding Source: researchfish
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Although best known for inducing inflammasome formation and pyroptosis in myeloid cells, increasing evidence highlights additional roles for Nod-like receptors (NLR) in nonhematopoietic cells. Two recent studies demonstrate that NLRX1 functions as an intrinsic tumor suppressor in intestinal epithelial cells (IEC), by regulating their responses to proliferative signals following intestinal injury.
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