Journal
TRENDS IN IMMUNOLOGY
Volume 37, Issue 6, Pages 386-398Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.04.003
Keywords
-
Categories
Funding
- Wellcome Trust [108065/Z/15/Z, MR/M007367/1]
- UK Department for International Development
- Medical Research Council
- Bill and Melinda Gates Foundation [OPP1131320]
- MRC [MR/M007367/1] Funding Source: UKRI
- Medical Research Council [MR/M007367/1] Funding Source: researchfish
- Bill and Melinda Gates Foundation [OPP1131320] Funding Source: Bill and Melinda Gates Foundation
Ask authors/readers for more resources
Malnutrition, which encompasses under- and overnutrition, is responsible for an enormous morbidity and mortality burden globally. Malnutrition results from disordered nutrient assimilation but is also characterized by recurrent infections and chronic inflammation, implying an underlying immune defect. Defects emerge before birth via modifications in the immunoepigenome of malnourished parents, and these may contribute to intergenerational cycles of malnutrition. This review summarizes key recent studies from experimental animals, in vitro models, and human cohorts, and proposes that immune dysfunction is both a cause and a consequence of malnutrition. Focusing on childhood undernutrition, we highlight gaps in current understanding of immune dysfunction in malnutrition, with a view to therapeutically targeting immune pathways as a novel means to reduce morbidity and mortality.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available