Journal
TRENDS IN GENETICS
Volume 32, Issue 10, Pages 638-659Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2016.07.004
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Funding
- Pew Charitable Trusts [00027373]
- Basil O'Connor Scholar Award from the March of Dimes Foundation [5-FY15-21]
- National Institutes of Health [R01EY025598]
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Across the animal kingdom, visual systems have evolved to be uniquely suited to the environments and behavioral patterns of different species. Visual acuity and color perception depend on the distribution of photoreceptor (PR) subtypes within the retina. Retinal mosaics can be organized into three broad categories: stochastic/regionalized, regionalized, and ordered. We describe here the retinal mosaics of flies, zebrafish, chickens, mice, and humans, and the gene regulatory networks controlling proper PR specification in each. By drawing parallels in eye development between these divergent species, we identify a set of conserved organizing principles and transcriptional networks that govern PR subtype differentiation.
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