Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 27, Issue 5, Pages 262-281Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2016.03.006
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Funding
- Netherlands Organization for Scientific Research (NWO-ZonMW) [VIDI 016.136.367]
- Academy of Finland
- Swedish Research Council
- Novo Nordisk Foundation
- Novo Nordisk Fonden [NNF15OC0016398] Funding Source: researchfish
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Genomic technologies have evolved rapidly contributing to the understanding of diseases. Genome-wide association studies (GWAS) and whole-exome sequencing have aided the identification of the genetic determinants of mono genic and complex conditions including osteoporosis and bone mass disorders. Overlap exists between the genes implicated in monogenic and complex forms of bone mass disorders, largely explained by the clustering of genes encoding factors in signaling pathways crucial for mesenchymal cell differentiation, skeletal development, and bone remodeling and metabolism. Numerous of the remaining discovered genes merit functional follow-up studies to elucidate their role in bone biology. The insight provided by genetic studies is serving the identification of biomarkers predictive of disease, redefining disease, response to treatment, and discovery of novel drug targets for skeletal disorders.
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