Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 27, Issue 9, Pages 633-642Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2016.06.011
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Funding
- JSPS KAKENHI grant [24591317, 24390056, 15K09380, 15K15599]
- Smoking Research Foundation
- Foundation for Growth Science
- Japan Diabetes Foundation
- Tamura Science and Technology Foundation
- Grants-in-Aid for Scientific Research [15K15599, 15K09380, 24390056, 24591317] Funding Source: KAKEN
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Modern lifestyles prolong daily activities into the nighttime, disrupting circadian rhythms, which may cause sleep disturbances. Sleep disturbances have been implicated in the dysregulation of blood glucose levels and reported to increase the risk of type 2 diabetes (T2D) and diabetic complications. Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including gamma-aminobutyric acid (GABA) agonists, melatonin agonists, and orexin receptor antagonists. A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. In this review we focus on the beneficial impact of sleep on glucose metabolism and suggest a possible strategy for therapeutic intervention against sleep-related metabolic disorders.
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