Journal
TRENDS IN CELL BIOLOGY
Volume 26, Issue 7, Pages 511-525Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.04.009
Keywords
-
Categories
Funding
- European Research Council (ERC-AdG) [232947]
- European H2020 EINFRA MuG grant
- CNRS
- INSERM
- European Network of Excellence EpiGeneSys
- Agence Nationale de la Recherche (EpiDevoMath)
- MMTT grant of the ITMO Cancer and INSEAM
- Laboratory of Excellence EpiGenMed
- French Ministry of Research
- European Research Council (ERC) [232947] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Polycomb group (PcG) proteins dynamically define cellular identities through the epigenetic repression of key developmental regulatory genes. PcG proteins are recruited to specific regulatory elements to modify the chromatin surrounding them. In addition, they regulate the organization of their target genes in the 3D space of the nucleus, and this regulatory function of the 3D genome architecture is involved in cell differentiation and the maintenance of cellular memory. In this review we discuss recent advances in our understanding of how PcG proteins are recruited to chromatin to induce local and global changes in chromosome conformation and regulate their target genes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available