Journal
TRENDS IN CELL BIOLOGY
Volume 26, Issue 2, Pages 111-120Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2015.09.009
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Funding
- National Cancer Institute [1RO1CA168689, 1R01CA174869, 1R21CA191442]
- American Cancer Society [RSG-09-282-01-CSM]
- DOD [W81XWH-13-1-0132]
- NIH [2T32CA067754, 5T32CA077109]
- ARCS Foundation
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The mechanical properties of the tumor microenvironment have been increasingly recognized as potent modulators of cell behavior and function. In particular, tissue rigidity is functionally important during tumor progression. In this review, we survey recent advances in our understanding of the role of tissue rigidity in tumor progression and metastasis, the mechanisms by which mechanical cues integrate with biochemical signals from the microenvironment, and the underlying mechanotransduction pathways involved in tumor progression. These findings highlight the importance of understanding and defining cellular mechanotransduction pathways and the breadth of signals derived from the tumor microenvironment that influence tumor progression.
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