Journal
TRENDS IN CELL BIOLOGY
Volume 26, Issue 9, Pages 655-667Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.04.006
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Funding
- Fondation pour la Recherche Medicale (FRM)
- Ligue Contre le Cancer (Equipe Labellisee)
- Agence National de la Recherche (ANR)-Projets Blancs
- ANR
- ERA-Net for Research on Rare Diseases
- Association Pour la Recherche sur le Cancer (ARC)
- Canceropole Ile-de-France
- Institut National du Cancer (INCa)
- Fondation Bettencourt-Schueller
- Fondation de France
- FRM
- European Commission (ArtForce)
- European Research Council (ERC)
- LabEx Immuno-Oncology
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
- Fondation pour la Recherche Medicale (FRM)
- Ligue Contre le Cancer (Equipe Labellisee)
- Agence National de la Recherche (ANR)-Projets Blancs
- ANR
- ERA-Net for Research on Rare Diseases
- Association Pour la Recherche sur le Cancer (ARC)
- Canceropole Ile-de-France
- Institut National du Cancer (INCa)
- Fondation Bettencourt-Schueller
- Fondation de France
- FRM
- European Commission (ArtForce)
- European Research Council (ERC)
- LabEx Immuno-Oncology
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
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Several insults cause the inner mitochondrial membrane to abruptly lose osmotic homeostasis, hence initiating a regulated variant of cell death known as `mitochondria' permeability transition' (MPT)-driven necrosis. MPT provides an etiological contribution to several human disorders characterized by the acute loss of post-mitotic cells, including cardiac and cerebral ischemia. Nevertheless, the precise molecular determinants of MPT remain elusive, which considerably hampers the development of clinically implementable cardio- or neuroprotective strategies targeting this process. We summarize recent findings shedding new light on the supramolecular entity that mediates MPT, the so-called 'permeability transition pore complex' (PTPC). Moreover, we discuss hitherto unresolved controversies on MPT and analyze the major obstacles that still preclude the complete understanding and therapeutic targeting of this process.
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