Journal
TRENDS IN CELL BIOLOGY
Volume 26, Issue 6, Pages 420-433Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.02.002
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Funding
- Human Frontier Science Program [RGP0040/2012]
- European Research Council under the European Union's Seventh Framework Programme [617233, 616480]
- Spanish Ministry of Economy and Competitiveness [BFU2012-38146]
- Generalitat de Catalunya [2014-SGR-927]
- Mechanobiology Institute
- Institut Universitaire de France
- ICREA Funding Source: Custom
- European Research Council (ERC) [616480] Funding Source: European Research Council (ERC)
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Directed cell migration is a complex process that involves front-rear polarization, characterized by cell adhesion and cytoskeleton-based protrusion, retraction, and contraction of either a single cell or a cell collective. Single cell polarization depends on a variety of mechanochemical signals including external adhesive cues, substrate stiffness, and confinement. In cell ensembles, coordinated polarization of migrating tissues results not only from the application of traction forces on the extracellular matrix but also from the transmission of mechanical stress through intercellular junctions. We focus here on the impact of mechanical cues on the establishment and maintenance of front rear polarization from single cell to collective cell behaviors through local or large-scale mechanisms.
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