Journal
TRENDS IN BIOTECHNOLOGY
Volume 34, Issue 3, Pages 228-241Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2015.12.005
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Concordia university Research Chair
- Fonds pour la Formation a la Recherche dens l'Industrie et dens l'Agriculture (FQRNT) DE Doctoral Research Scholarship
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Benzylisoquinoline alkaloids (BIAs) are a family of similar to 2500 alkaloids with both potential and realized pharmaceutical value, including most notably the opiates such as codeine and morphine. Only a few BIAs accumulate readily in plants, which limits the pharmaceutical potential of the family. Shifting BIA production to microbial sources could provide a scalable and flexible source of these compounds in the future. This review details the current status of microbial BIA synthesis and derivatization, including rapid developments in the past 6 months culminating in the synthesis of opioids from glucose in a microbial host.
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