Journal
TRENDS IN BIOTECHNOLOGY
Volume 34, Issue 4, Pages 276-290Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2015.12.013
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Funding
- Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST, from the Japan Science and Technology Agency (JST)
- Humeri Frontier Science Project (HFSP) grant [RGP0061/2011]
- Japan Diabetes Foundation
- Japan Society for the Promotion of Science [15H05582]
- 'Creation of Innovative Technology for Medical Applications Based on the Global Analyses and Regulation of Disease-Related Metabolites', PRESTO, from JST
- MEXT [25117712]
- 'Elucidation and regulation in the dynamic maintenance and transfiguration of homeostasis in living body', PRESTO, from JST
- Grants-in-Aid for Scientific Research [15H05582, 25117712] Funding Source: KAKEN
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We propose 'trans-omic' analysis for reconstructing global biochemical networks across multiple omic layers by use of both multi-omic measurements and computational data integration. We introduce technologies for connecting multi-omic data based on prior knowledge of biochemical interactions and characterize a biochemical trans-omic network by concepts of a static and dynamic nature. We introduce case studies of metabolism-centric trans-omic studies to show how to reconstruct a biochemical trans-omic network by connecting multi-omic data and how to analyze it in terms of the static and dynamic nature. We propose a trans-ome-wide association study (trans-OWAS) connecting phenotypes with trans-omic networks that reflect both genetic and environmental factors, which can characterize several complex lifestyle diseases as breakdowns in the trans-omic system.
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