Journal
TRENDS IN BIOTECHNOLOGY
Volume 34, Issue 2, Pages 156-170Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2015.11.001
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Funding
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/C013204/1] Funding Source: researchfish
- National Centre for the Replacement, Refinement and Reduction of Animals in Research [NC/C013204/1] Funding Source: Medline
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Improved model systems to predict drug efficacy, interactions, and drug induced kidney injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and DIKI. We also discuss high-throughput screening and the challenges for in vitro to in vivo extrapolation (IVIVE) that will need to be overcome for successful implementation.
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