Journal
TRENDS IN BIOTECHNOLOGY
Volume 34, Issue 3, Pages 191-197Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2015.11.002
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- BE-BASIC program Itaconic/Fumaric Acids: Novel Economic and Eco-efficient Processes for the Production of Itaconic and Fumaric Acid [FS 01.002]
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The tricarboxylic acid (TCA) cycle has been used for decades in the microbial production of chemicals such as citrate, L-glutamate, and succinate. Maximizing yield is key for cost-competitive production. However, for most TCA cycle products, the maximum pathway yield is lowerthan the theoretical maximum yield (YE). For succinate, this was solved by creating two pathways to the product, using both branches of the TCA cycle, connected by the glyoxylate shunt (GS). A similar solution cannot be applied directly for production of compounds from the oxidative branch of the TCA cycle because irreversible reactions are involved. Here, we describe how this can be overcome and what the impact is on the yield.
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