Journal
TRENDS IN BIOTECHNOLOGY
Volume 34, Issue 8, Pages 627-637Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2016.02.016
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Funding
- Sir Henry Wellcome Fellowship [098847/Z/12/Z]
- Wellcome Trust [098847/Z/12/Z] Funding Source: Wellcome Trust
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Tissues comprise multiple heterotypic cell types (e.g., epithelial, mesenchymal, and immune cells). Communication between heterotypic cell types is essential for biological cohesion and is frequently dysregulated in disease. Despite the importance of heterocellular communication, most systems biology techniques do not report cell-specific signaling data from mixtures of cells. As a result, our existing perspective of cellular behavior under-represents the influence of heterocellular signaling. Recent technical advances now permit the resolution of systems-level cell-specific signaling data. This review discusses how new physical, spatial, and isotopic resolving methods are facilitating unique systems biology studies of heterocellular communication.
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