Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 41, Issue 11, Pages 954-969Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.08.010
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Funding
- National Institute of General Medical Sciences [R01 GM105724]
- National Institute of Diabetes and Digestive and Kidney Diseases [P30DK056341]
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Lipidomics is a newly emerged discipline that studies cellular lipids on a large scale based on analytical chemistry principles and technological tools, particularly mass spectrometry. Recently, techniques have greatly advanced and novel applications of lipidomics in the biomedical sciences have emerged. This review provides a timely update on these aspects. After briefly introducing the lipidomics discipline, we compare mass spectrometry-based techniques for analysis of lipids and summarize very recent applications of lipidomics in health and disease. Finally, we discuss the status of the field, future directions, and advantages and limitations of the field.
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