Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 41, Issue 12, Pages 1035-1049Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.09.001
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Funding
- European Research Council (ERC mitoCalcium) [294777]
- Italian Telethon Foundation [GPP10005A]
- Italian Ministry of Heath (Ricerca Finalizzata)
- Italian Ministry of Education, University, and Research (PRIN)
- Italian Ministry of Education, University, and Research (FIRB)
- Italian Ministry of Education, University, and Research (FIRB Futuro in Ricerca) [RBFR10EGVP_002]
- NIH [1P01AG025532-01A1]
- Cariparo Foundation
- Cariplo Foundation
- Italian Association for Cancer Research (AIRC)
- French Muscular Dystrophy Association [19471, 18857]
- European Research Council (ERC) [294777] Funding Source: European Research Council (ERC)
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In recent years, rapid discoveries have been made relating to Ca2+ handling at specific organelles that have important implications for whole-cell Ca2+ homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca2+ channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca2+ signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca2+ signaling. In this review we summarize recent discoveries on the regulation of interorganellar Ca2+ homeostasis and its role in pathophysiology.
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