Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 41, Issue 9, Pages 784-797Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.06.002
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Funding
- Danish Council for Independent Research [1331-00254]
- Novo Nordisk Foundation [11535]
- University of Copenhagen
- Lundbeck Foundation [R54-2010-5375] Funding Source: researchfish
- Novo Nordisk Fonden [NNF14OC0011535, NNF15OC0016886] Funding Source: researchfish
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Primary cilia are dynamic signaling organelles that project from the cell surface to sense diverse chemical, physical and morphogenetic cues. Ciliary defects therefore cause diseases (ciliopathies) that affect multiple organs in developing and adult organisms. Cilia-mediated signaling involves the orchestrated movement of signaling proteins in and out of the ciliary compartment, including movement of receptors such as the Sonic Hedgehog (Shh) receptor Patched 1 (PTCH1), Smoothened (SMO), and various other G protein-coupled receptors (GPCRs), as well as transforming growth factor beta (TGF-beta) receptors I and II (TGF-beta-RI/II). We provide here a current understanding of trafficking events associated with cilia-mediated signaling, with emphasis on the involvement of clathrin-dependent receptor-mediated endocytosis in regulating ciliary Shh and TGF-beta signaling.
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