Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 41, Issue 6, Pages 475-477Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.04.007
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Funding
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [1209923] Funding Source: researchfish
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Two-pore channels (TPCs) are intracellular Ca2+-permeable ion channels that are expressed on acidic Ca2+ stores. They are co regulated by voltage and Ca2+ in plant vacuoles and by the second messenger NAADP in animal endolysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.
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