Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 41, Issue 8, Pages 650-653Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.04.008
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- Wellcome Trust Funding Source: Medline
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A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid MS allowing characterization of challenging biological systems.
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