Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 41, Issue 5, Pages 390-393Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.03.006
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The uncontrolled proliferation of cancer cells requires functional mitochondrial metabolism, which uses Ca2+ as a cofactor. IP3 receptors (IP(3)Rs) from endoplasmic reticulum (ER) Ca2+ stores provide the supply of Ca2+ to mitochondria. A new study by Cardenas et al. shows that, in contrast to normal cells, cancer cells critically depend on ER-mitochondrial Ca2+ fluxes for their survival by sustaining the production of mitochondrial substrates used for nucleotide biosynthesis and proliferation.
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