Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 41, Issue 12, Pages 998-1011Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.08.015
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Funding
- VENI grant [863.11.003]
- European Research Council (ERC) [640422]
- European Research Council (ERC) [640422] Funding Source: European Research Council (ERC)
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Anaerobic ammonium-oxidizing (anammox) bacteria are one of the latest scientific discoveries in the biogeochemical nitrogen cycle. These microorganisms are able to oxidize ammonium (NH4+) with nitrite (NO2-) as the oxidant instead of oxygen and form dinitrogen (N-2) as the end product. Recent research has shed a light on the biochemistry underlying anammox metabolism with two key intermediates, nitric oxide (NO) and hydrazine (N2H4). Substrates and intermediates are converted exploiting the catalytic and electron-transfer potentials of c-type heme proteins known from numerous biochemical reactions and that have acquired new functionality in anammox biochemistry. On a global scale, anammox bacteria significantly contribute to the removal of fixed nitrogen from the environment and the process finds rapidly increasing interest in wastewater treatment
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