Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 41, Issue 7, Pages 621-632Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.04.005
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Funding
- National Institutes of Health (NIH) [5T32GM008322, 1R21AG050903, R21AG045432, 1R01DK102850]
- American Diabetes Association [1-13-BS-106, 1-16-JDF-017]
- Ellison Medical Foundation [AG-NS-0932-12]
- MCubed Research Initiatives from the University of Michigan
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Excessive accumulation of reactive oxygen species (ROS) and chronic activation of mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) are well-characterized promoters of aging and age-associated degenerative pathologies. Sestrins, a family of highly conserved stress-inducible proteins, are important negative regulators of both ROS and mTORC1 signaling pathways; however, the mechanistic basis of how Sestrins suppress these pathways remains elusive. In the past couple of years, breakthrough discoveries about Sestrin signaling and its molecular nature have markedly increased our biochemical understanding of Sestrin function. These discoveries have also uncovered new potential therapeutic strategies that may eventually enable us to attenuate aging and age-associated diseases.
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