Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 18, Issue 6, Pages 960-964Publisher
WILEY-BLACKWELL
DOI: 10.1111/tid.12607
Keywords
astrovirus VA1-HMO-C; BMT; deep brain sequencing; unexplained encephalitis
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Funding
- Great Ormond Street Hospital Childrens Charity [W1068] Funding Source: researchfish
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Neuroinvasive astrovirus (VA1-HMO-C) is an emerging life-threatening infection in immunocompromised hosts. We describe an 8-month-old child who died of VA1/HMO-C encephalitis following bone marrow transplantation. The diagnosis was only made post-mortem using RNA deep sequencing of the brain. Repeat analysis of the post-mortem brain tissue using polymerase chain reaction specific primers for VA1/HMO-C was positive. Astrovirus VA1/HMO-C should be included in the evaluation of patients with similar encephalitis.
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