Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 18, Issue 5, Pages 768-772Publisher
WILEY
DOI: 10.1111/tid.12577
Keywords
trichosporonosis; Trichosporon asahii; hematopoietic stem cell transplant; aplastic anemia; central nervous system infection; hydrocephalus
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Trichosporon is an ubiquitous yeast that has emerged as an opportunistic pathogen in the immunocompromised host. We describe a case of invasive trichosporonosis in an allogeneic hematopoietic stem cell transplant (allo-HSCT) recipient while on caspofungin antifungal prophylaxis. She developed disseminated trichosporonosis in the pre-engraftment period and was successfully treated with voriconazole. She later developed 2 further episodes of invasive trichosporonosis involving the central nervous system. This case highlights the challenges of managing trichosporonosis in allo-HSCT recipients and suggests the need for lifelong therapy in some patients.
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