Journal
TRAFFIC
Volume 17, Issue 12, Pages 1244-1261Publisher
WILEY
DOI: 10.1111/tra.12417
Keywords
3D culture; apical transport; cell polarity; Crumbs; endocytosis; epithelia; exocytosis; lumen formation; morphogenesis; Podocalyxin; Rab GTPases; trafficking
Categories
Ask authors/readers for more resources
The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization. What is much less appreciated is that underpinning an asymmetric cell surface is an equally dramatic intracellular endosome rearrangement. Here, we review the interplay between classical cell polarity proteins and membrane trafficking pathways, and discuss how this marriage gives rise to cell polarization. We focus on those mechanisms that regulate apical polarization, as this is providing a number of insights into how membrane traffic and polarity are regulated at the tissue level.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available