Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 80, Issue -, Pages 57-65Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2016.02.017
Keywords
Solid-phase microextraction; Endogenous metabolite; Metabolomics; Pharmaceuticals; Medical diagnosis; Microorganisms
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Funding
- Fundamental and Frontier Research Fund of Chongqing [cstc2014jcyjA10108]
- Fundamental Research Funds for the Central Universities [CQDXWL-2014-Z007, CQDXWL-2012-031]
- Special Fund for Basic Scientific Research of Central Colleges, Chongqing University [201310611045]
- Tang Foundations
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Analysis of endogenous metabolites in biological samples may lead to the identification of biomarkers in metabolomics studies. To achieve accurate sample analysis, a combined method of continuous quick sampling and extraction is required for online compound detection. Solid-phase microextraction (SPME) integrates sampling, extraction and concentration into a single solvent-free step for chemical analysis. SPME has a number of advantages, including simplicity, high sensitivity and a relatively non-invasive nature. In this article, we reviewed SPME technology in in vitro and in vivo analyses of metabolites after the ingestion of herbal medicines, foods and pharmaceutical agents. The metabolites of microorganisms in dietary supplements and in the gastrointestinal tract will also be examined. As a promising technology in biomedical and pharmaceutical research, SPME and its future applications will depend on advances in analytical technologies and material science. (C) 2016 Elsevier B.V. All rights reserved.
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