Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 85, Issue -, Pages 181-202Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2016.09.006
Keywords
Reactive oxygen species; Fluorescent probes; Luminescent probes; Multi-functional probes; Ratiometric probes; Biological systems
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Funding
- Jiangsu Provincial Natural Science Foundation [BK20150689, BK 20151445]
- Jiangsu Provincial Key Research and Development Program [BE2016745]
- Open Project Program of MOE Key Laboratory of Drug Quality Control and Pharmacovigilance [DQCP2015QN01]
- National Natural Science Foundation of China [81673390]
- Fundamental Research Funds for the Central Universities [2015PY010, 2015ZD008]
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Reactive oxygen species (ROS) are chemically reactive molecules that can mediate a wide variety of biological processes. The imbalance of these reactive intermediates in the metabolism will result in the phenomenon known as oxidative stress. Therefore, a great number of approaches have been developed for measuring ROS in biological systems. Due to their reactive and transient nature, the ROS are generally difficult to determine. Fluorescent and luminescent probes for monitoring ROS have shown advantages such as high sensitivity, selectivity, as well as real-time imaging, which can yield visible information about the ROS. The recent progress in preparing ROS probes (including small organic molecules, metal complexes or nanomaterials) for detecting and imaging of ROS production in living cells or whole organisms were summarized in this review. The design strategies and ROS sensing mechanisms of these functional probes were described. (C) 2016 Elsevier B.V. All rights reserved.
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