Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 80, Issue -, Pages 495-506Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2016.04.001
Keywords
Mixed-mode; Multi-mode; High-performance liquid chromatography; Stationary phase materials; Mixed ligands; Preparation; Characterization
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Funding
- 100 Young Plan by Chongqing University [0236011104410]
- NSFC [21303179]
- Fundamental Research Funds for the Central Universities of China [106112015CDJZR465505]
- Project of Science and Technology Development Plan for Jilin Province [20140101117JC]
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Mixed-mode high-performance liquid chromatography (MHPLC) is a type of chromatographic technique with extraordinary separation properties, such as adjustable selectivity, high resolution and high sample loading capacity. As the name suggests, MHPLC utilizes more than one forms of interactions between the stationary phases and the solutes for multi-mode chromatographic retention mechanisms, and thus one MHPLC column may replace two or more traditional single mode columns. The physiochemical properties of mixed-mode stationary phase materials are the foundation of the development of MHPLC. The current review describes recent advances in materials for stationary phases of MHPLC. Furthermore, the related aspects of MHPLC materials such as preparation, characterization and application are also summarized. Future outlooks in this rapidly developing field are also discussed. (C) 2016 Elsevier B.V. All rights reserved.
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