Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 290, Issue -, Pages 86-97Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2015.11.016
Keywords
Hepatotoxicity; Acute liver failure; Acetaminophen; D-galactosamine; Fas ligand; Concanavalin A
Categories
Funding
- Agency for Innovation by Science and Technology in Flanders (IWT) [131003]
- European Research Council (ERC) [335476]
- Fund for Scientific Research-Flanders (FWO) [G009514N, G010214N]
- University Hospital of the Vrije Universiteit Brussel Belgium (Willy Gepts Fonds UZ-VUB)
- National Institutes of Health [R01 DK102142, R01 AAl2916]
- National Center for Research Resources [5P20RR021940]
- National Institute of General Medical Sciences from the National Institutes of Health [8 P20 GM103549]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR021940] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK102142, R01DK070195] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM103549] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA012916] Funding Source: NIH RePORTER
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Acute liver failure can be the consequence of various etiologies, with most cases arising from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the management of acute liver failure continues to be one of the most challenging problems in clinical medicine. The availability of adequate experimental models is of crucial importance to provide a better understanding of this condition and to allow identification of novel drug targets, testing the efficacy of new therapeutic interventions and acting as models for assessing mechanisms of toxicity. Experimental models of hepatotoxicity related to acute liver failure rely on surgical procedures, chemical exposure or viral infection. Each of these models has a number of strengths and weaknesses. This paper specifically reviews commonly used chemical in vivo and in vitro models of hepatotoxicity associated with acute liver failure. (C) 2015 Elsevier Inc. All rights reserved.
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