Journal
TOXICOLOGY
Volume 368, Issue -, Pages 80-90Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2016.08.005
Keywords
MicroRNA; Hepatic detoxification; Phase I enzymes; Phase II enzymes; Phase III enzymes
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Funding
- National Natural Science Foundation of China [81500479, 81230062]
- SRF for ROCS, SEM
- Southwest Hospital Grant [SWH2014QN09]
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MicroRNAs (miRNAs) are a class of short noncoding RNA5 that modulate gene expression at both transcriptional and post-transcriptional levels. Many studies have extensively revealed the significance of miRNAs in mediating liver development and diseases. However, their role in hepatic detoxification processes has been explored only recently. In this review, we summarized the up-to-date knowledge about miRNA dependent regulation of enzymes involved in all three phases of the drugs and xenobiotics detoxification process. We also discussed the role of miRNA in regulating some upstream nuclear receptors involving gene expression of enzymes for detoxification process in liver. The toxicological significance of miRNAs in liver diseases and future research perspectives are finally presented. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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