Journal
THERMOCHIMICA ACTA
Volume 634, Issue -, Pages 48-56Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.tca.2016.03.025
Keywords
DSC; HPTLC; Pseudoephedrine; Dextropropoxyphene; Tramadol; Paracetamol
Funding
- Project CNEPRU(MESRS) [E00220130108]
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In this paper, we report a DSC investigation of solid-liquid equilibria in three binary mixtures of paracetamol, namely with pseudoephedrine, dextropropoxyphene and tramadol, resulting in a temperature-composition phase diagrams with eutectic equilibrium. Eutectic mole fractions, temperatures and enthalpies were determined and reported for each system. The study reports also a direct exploitation of the DSC results for the quantification purpose, which were in good agreement with those obtained by a standard analytical method namely high performance thin layer chromatography (HPTLC), used in this work for comparison purpose. (C) 2016 Published by Elsevier B.V.
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