Journal
THERIOGENOLOGY
Volume 85, Issue 7, Pages 1282-1288Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.theriogenology.2015.12.013
Keywords
Postpartum cows; Uterine infection; Innate immunity; Toll-like receptors; NOD-like receptors
Categories
Funding
- FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas Gerais, Belo Horizonte, Brazil) [APQ 02489-10]
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brasilia, Brazil)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brasilia, Brazil
- DVM Foundation
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Changes in the endometrial transcription of pattern recognition receptors may increase the susceptibility to postpartum uterine infections in Holstein cows with retained placenta. To test this hypothesis, nine cows with retained placenta and ten cows without retained placenta were submitted to endometrial biopsies at the first and seventh days postpartum. Cows were monitored weekly with clinical and gynecological examinations until 42 days postpartum. Samples of the uterine contents were collected weekly for aerobic bacteria isolation. All cows had endometrial transcription of Toll-like receptors (TLRs) 1/6, 2, 4, 5, and 9; nucleotide-binding oligomerization domain (NOD)-like receptors 1 and 2; and the coreceptors cluster of differentiation 14 (CD14) and myeloid differentiation protein-2 (MD 2), as measured on the first and seventh days postpartum. Escherichia coli was the most common bacterium isolated from the uterine contents of cows with or without retained placenta until 21 days postpartum. Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased (P < 0.05) between the first and the seventh day postpartum. Conversely, cows without retained placenta did not have any significant changes in transcription levels between these time points. (C) 2016 Elsevier Inc. All rights reserved.
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