Journal
TETRAHEDRON-ASYMMETRY
Volume 27, Issue 16, Pages 732-739Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2016.06.018
Keywords
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Funding
- Natural Science Foundation of Liaoning Province of China [2015020246]
- Foundation of University of Science and Technology Liaoning [2015TD02]
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A series of chiral amino alcohol ligands was prepared using commercial amino alcohols and phthalaldehydes. These ligands were used as catalysts in asymmetric Henry reactions in the presence of Cu(II) ions giving good yields (up to 97%) and enantiomeric excesses (ee, up to 98%). The DFT calculations showed the effect of the trans/cis configurations of the Cu-complexes on the origin of enantioselectivity. The easy catalyst preparation, mild reaction conditions, high yields and excellent enantioselectivities make these catalysts suitable for widespread use. (C) 2016 Elsevier Ltd. All rights reserved.
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