Recent advances in trifluoromethylthiolation using nucleophilic trifluoromethylthiolating reagents

With regard to the high lipophilicity of the trifluoromethylthio group (CF3S-), there is a growing interest in the development of efficient methods for the incorporation of CF3S moiety onto organic molecules. In this review, recent advances in trifluoromethylthiolation using nucleophilic trifluoromethylthiolating reagents are discussed, highlighting some of the most intriguing examples of the synthesis of trifluoromethylthio-containing compounds using novel reagents. (C) 2016 Elsevier Ltd. All rights reserved.