Regioselective synthesis of bifuroxanyl systems with the 3-nitrobifuroxanyl core via a one-pot acylation/nitrosation/cyclization cascade

A regioselective method for the synthesis of previously unknown bifuroxanyl systems containing the 3-nitrobifuroxanyl core, based on a cascade of one-pot reactions comprising of the acylation of dinitromethane sodium salt with furoxanyl hydroxamic acid chlorides, nitrosation of the acylation product with NaNO2/AcOH/AcONa, and intramolecular cyclization of the nitrosation product to give the 3-nitrobifuroxanyl moiety, has been developed. (C) 2016 Elsevier Ltd. All rights reserved.