Four-component, five-centered, one-pot synthesis of 1-(1H-tetrazol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole derivatives

An efficient four component, five centered coupling strategy has been developed for the synthesis of a novel series of 1-tetrazolyl-tetrahydro-beta-carboline derivatives in good yields. This method is effective for the synthesis of tetrazolyl tetrahydro-beta-carbolines in a one-pot operation. This method is operationally simple and works under mild conditions with diverse substrates. (C) 2016 Elsevier Ltd. All rights reserved.