Journal
TETRAHEDRON LETTERS
Volume 57, Issue 7, Pages 796-799Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.01.030
Keywords
Periconia; Endophytic fungus; Cytochalasan; Periconiasin
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Funding
- National Natural Science Foundation of China [31170041, 81402835]
- National High Technology Research and Development Program of China [2012AA091606]
- National Infrastructure of Microbial Resources [NIMR-2015-3]
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Two new cytochalasans, periconiasin G (1) and periconiasin H (2) were isolated from endophytic fungus Periconia sp. F-31. Compound 1 is the first cytochalasan with a 71615 tricyclic ring system, and compound 2 possesses a rare sulfoxide group. Their structures including absolute configurations were elucidated by extensive spectroscopic analyses and ECD calculations. A possible biogenetic pathway for these two compounds was proposed. Compound 1 showed weak anti-HIV activity with IC50 value of 67.0 mu M. (C) 2016 Elsevier Ltd. All rights reserved.
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