Journal
TETRAHEDRON LETTERS
Volume 57, Issue 2, Pages 163-167Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.11.056
Keywords
(E,E)-1,3-Bis(arylidene)indan-2-one; 1,3-Dipolar cycloaddition; Azomethine ylide; Mycobacterium tuberculosis
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Non-stabilized azomethine ylides, generated in situ from isatin derivatives and c-proline, have been reacted with (E,E)-1,3-bis(arylidene)indan-2-ones as dipolarophiles in a 1,3-dipolar cycloaddition reaction. Novel functionalized dispiroheterocyclic compounds were obtained with low diastereoselectivity and the regiochemical outcome of the cycloaddition reaction was confirmed by single crystal X-ray analysis. The compounds were investigated by in vitro screening against Mycobacterium tuberculosis (MIC) using the agar dilution method and displayed good activities. (C) 2015 Elsevier Ltd. All rights reserved.
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