Journal
TETRAHEDRON LETTERS
Volume 57, Issue 21, Pages 2315-2319Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.04.056
Keywords
Lithium hydroxide; Ethanol; Pyrrole; TosMIC; Ylide
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Funding
- department of science and technology (DST), Government of India
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A convenient synthesis of 4-alkyl-3-benzoyl pyrrole was achieved from alpha,beta-unsaturated ketones and tosylmethyl isocyanide in the presence of mild base LiOH center dot H2O. This method is very economical and was successfully utilized for the synthesis of various 4-alkyl-3-benzoylpyrrole derivatives with good to excellent yields. (C) 2016 Elsevier Ltd. All rights reserved.
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