4.4 Article

α-Alltylation of tertiary amines by C(sp3)-C(sp3) cross-coupling under redox neutral photocatalysis

Journal

TETRAHEDRON LETTERS
Volume 57, Issue 40, Pages 4480-4483

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.08.073

Keywords

Photo chemistry; C-H alkylation; Visible light; C(sp)(3)-C(sp)(3) C-H coupling; Tertiary amine

Funding

  1. DST, New Delhi

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Direct cc-alkylation of N-phenyl-tetrahydroisoquinoline with alkyl selenides of desired alkyl chain length and functionality is reported by photoredox catalysis. Construction of hexahydro pyrrolo- and pyrido-isoquinoline scaffolds along with indolines and tetrahydroquinolines is also described by intramolecular C(sp(3))-C(sp(3)) cross-couplings. (C) 2016 Elsevier Ltd. All rights reserved.

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