Journal
TETRAHEDRON LETTERS
Volume 57, Issue 3, Pages 446-448Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.12.051
Keywords
Scytophycin C; Catalytic asymmetric thioamide-aldol reaction; Natural product synthesis; Cytotoxic agent
Categories
Funding
- JST, ACT-C
- Grants-in-Aid for Scientific Research [15F15412] Funding Source: KAKEN
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We achieved a formal total synthesis of scytophycin C. The synthesis demonstrates the utility of the catalytic asymmetric direct thioamide-aldol reaction for the preparation of polyketide structures, and was accomplished via diastereoselective allylation, and allylative cyclization as other key transformations. The reported process accesses Miyashita's key fragment corresponding to the C7-C18 framework in fewer steps (14 steps) than in previously reported syntheses. (C) 2015 Elsevier Ltd. All rights reserved.
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